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Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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DBCO-sulfo-link-biotin is a cleavable linker reagent that combines a dibenzocyclooctyne (DBCO) reactive group with a sulfonated biotin tag for aqueous solubility and affinity capture. It is intended for click chemistry applications such as strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing biomolecules and for use in the synthesis of antibody-drug conjugates. For research use only.
Enables SPAAC with azide-functionalized biomolecules.
Contains a sulfonated biotin tag for aqueous solubility and affinity capture.
Cleavable linker suitable for antibody-drug conjugate synthesis.
Soluble in DMSO at high concentrations and formulatable for in vivo use.
Powder stable at -20°C; solutions stable at -80°C for extended storage.
Available in small milligram quantities for research workflows.
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A natural triterpene which stimulates wound healing; induces cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 µM for MCF-7 cells); blocks angiogenesis in glioblastomas; down regulates BACE1 while increasing ADAM10 maturation in primary rat cortical neurons; protects against neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice
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trans-Sulfo-SMCC is a non-cleavable, membrane-permeable crosslinker used for antibody-drug conjugate (ADC) construction and general bioconjugation. It contains maleimide and N-hydroxysuccinimide (NHS) ester functionalities that enable stable conjugation between sulfhydryl and amino groups to form non-cleavable linkages.
Non-cleavable linker suitable for ADC construction.
Membrane permeable for potential intracellular delivery.
Maleimide and NHS-ester reactive groups for thiol-to-amine conjugation.
Solid, white to off-white, available in multiple quantities including 100 mg.
Stable as a powder at -20 °C for long-term storage; in solvent stability varies.
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A sesquiterpene; decreases triglyceride levels and GPDH activity in hAMSCs; inhibits adipocyte differentiation at 200 µM; decreases C/EBPα and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
DMABA NHS ester is the N-hydroxysuccinimide ester of DMABA, a reactive labeling reagent used to derivatize primary amines for detection and analysis in biochemical workflows. It is supplied as a high-purity solid and is suitable for research applications requiring amine-specific tagging.
Reactive toward primary amines for labeling and conjugation.
Suitable for phospholipid, peptide, and protein derivatization for MS or fluorescence detection.
High purity ensures minimal side products during reactions.
Supplied as a solid for convenient storage and handling.
Store sealed, away from moisture; long-term storage at -20°C recommended.
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VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Apoquel Chewable (oclacitinib chewable tablet) is an oral chewable tablet that works differently from other skin allergy medications for dogs. It goes straight to the source to help relieve itch and inflammation at its core. Provides rapid relief from allergic dermatitis and has demonstrated to control allergic pruritus within 24 hours. Addresses the underlying cause of irritation and soothes allergic reactions For dogs older than 12 months of age to help lessen itch and inflammation due to allergic dermatitis Ideal for both short- or long-term treatment and can help to offer relief without many of the side effects associated with other medications
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An inhibitor of mitochondrial dysfunction; increases intracellular ATP levels in Hep3B cells at a 3 µM; rescues LPS-induced apoptosis and decreases in the mitochondrial membrane potential in BV-2 microglial cells at 5 µM; protects against BSO-induced decreases in cell viability in fibroblasts isolated from patients with various mitochondrial diseases (EC50s = 2.3-5.1 µM) in an electron transport chain-independent manner; reduces plasma levels of creatinine and decreases acute renal tubular necrosis in a mouse model of bilateral retroperitoneal renal ischemia-reperfusion injury at 50 mg/kg
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MW 368.34 Da, Purity >99%. Homobifunctional primary amine reactive cross-linker. Contains an 8 atom linker (11.4 Å) and can cross-link distances up to ~25 Å due to protein flexibility. Produces no toxic side products.